BUSINESS CENTERS: CLASSIFICATIONS, MAIN PROPERTIES AND REQUIREMENTS

Business centers are becoming one of the most important architectural components of modern cities; the need of such centers became a demand due to the concentration of high number of businesses and international businesses within big cities, which created the demand of an architectural cluster of business centers that facilitates running business between enterprises and keep the high concentration of financial flow within one zone.To understand this concept; the article will first note the most important business centers of our modern world, the percentage of companies present, and the medium rental cost. The financial components plays a huge role when it comes to business centers; as they always need funding to be realized, and to be funded they need to be able to produce an equivalent value and profit; in other terms they need to be self-independent buildings, to be able to understand that we need to take a look at the current examples in our world.Moreover, it’s very important to understand the different types of business centers, as they provide a variety of different services not to mention the importance of understanding location requisites depending on the type of business center. In this article the main classification of business centers is explained briefly with an example.Urban requirements and importance is discussed briefly as it is important to understand the concept of CBD (Central Business District) and how it reflects on the hosting cities in many different ways. As our urban formation is changing slowly and architectural demands are changing, it’s important to plan for our future cities to fulfill the objective and create flexibility and comfort, and avoid future complication and unnecessary waste of cost

ARCHITECTURE STUDY OF THENOLD CITY PART OF HOMS

The article is devoted to the study of the current situation in Syria in the city of Homs. The subject of analysis is urban, architectural and social status of Homs neighborhood. The authors aims to give a detailed study of a typical old-Homs neighborhood. An in-depth examination to modify part of the old city of Homs to rearrange and organize the spaces and the formation of fasades in an effort to preserve the architectural heritage scheme.The basis of the research is the comparative methods and collecting of current information and leading to the results.The results of the study are that the authors professional opinion that leads to a better status of the architecture and urban situation in the old city of Homs.The authors supposes that with minimal but well studied interventions to the urban and architecture structure of the old city of Homs we can keep its traditional face for closer link between the new generations and their ancestors.The results of the study can be applied in the sphere of urban planning and architectural design

THE STUDY OF BUSINESS CENTERS IN THE ARABIAN GULF: RESIDENTIAL, OFFICES, AND COMMERCIAL BUILDINGS

The modern architecture of the Arabian Gulf has become an international icon after the completion of Burj Al Arab in 1999. Since then, many more modern buildings were built in order to host the numerous international companies residing or branching in the Arabian Gulf especially in Dubai.This article will examine few examples of the modern architecture the Arabian Gulf, some of many amazing projects were constructed, alongside a brief introduction, what challenges the architecture faces in the Arabian Gulf, and what’s the future seems like

Sirtuin 1 inhibiting thiocyanates (S1th)-a new class of isotype selective inhibitors of NAD(+) dependent lysine deacetylases

Sirtuin 1 (Sirt1) is a NAD(+) dependent lysine deacetylase associated with the pathogenesis of various diseases including cancer. In many cancer types Sirt1 expression is increased and higher levels have been associated with metastasis and poor prognosis. However, it was also shown, that Sirt1 can have tumor suppressing properties and in some instances even a dual role for the same cancer type has been reported. Increased Sirt1 activity has been linked to extension of the life span of cells, respectively, organisms by promoting DNA repair processes and downregulation of tumor suppressor proteins. This may have the downside of enhancing tumor growth and metastasis. In mice embryonic fibroblasts depletion of Sirt1 was shown to decrease levels of the DNA damage sensor histone H2AX. Impairment of DNA repair mechanisms by Sirt1 can promote tumorigenesis but also lower chemoresistance toward DNA targeting therapies. Despite many biological studies, there is currently just one small molecule Sirt1 inhibitor in clinical trials. Selisistat (EX-527) reached phase III clinical trials for treatment of Huntington's Disease. New small molecule Sirt1 modulators are crucial for further investigation of the contradicting roles of Sirt1 in cancer. We tested a small library of commercially available compounds that were proposed by virtual screening and docking studies against Sirt1, 2 and 3. A thienopyrimidone featuring a phenyl thiocyanate moiety was found to selectively inhibit Sirt1 with an IC50 of 13 mu M. Structural analogs lacking the thiocyanate function did not show inhibition of Sirt1 revealing this group as key for the selectivity and affinity toward Sirt1. Further analogs with higher solubility were identified through iterative docking studies and in vitro testing. The most active compounds (down to 5 mu M IC50) were further studied in cells. The ratio of phosphorylated gamma H2AX to unmodified H2AX is lower when Sirt1 is depleted or inhibited. Our new Sirtuin 1 inhibiting thiocyanates (S1th) lead to similarly lowered gamma H2AX/H2AX ratios in mouse embryonic fibroblasts as Sirt1 knockout and treatment with the reference inhibitor EX-527. In addition to that we were able to show antiproliferative activity, inhibition of migration and colony forming as well as hyperacetylation of Sirt1 targets p53 and H3 by the S1th in cervical cancer cells (HeLa). These results reveal thiocyanates as a promising new class of selective Sirt1 inhibitors.Chemical Immunolog

CLAY ARCHITECTURE IN SYRIA

The article is devoted to the study of clay houses in Syria. The subject of analysis is the architectural and structural form of clay houses. The authors strive to give a detailed description of typical beehive houses in Syria, in-depth study of their symbolic form and eco-architecture, and the ability to use them effectively.The study set comparatives methods and charge current information, which leads to the results.The results of the study is the author’s professional opinion on the modernization of the use of clay houses in Syria, to meet the needs of modern living standards.The authors believe that with its great flexibility and adaptability to extreme weather conditions, the beehive houses with its materials and methods of construction can be used for eco- friendly modernization of green buildings.The research results can be applied in the field of eco-friendly architectural design

Potent and Selective Inhibitors of Human Sirtuin 5

Sirtuins are protein deacylases that regulate metabolism and stress responses and are implicated in aging-related diseases. Modulators of the human sirtuins Sirt1–7 are sought as chemical tools and potential therapeutics, e.g., for cancer. Selective and potent inhibitors are available for Sirt2, but selective inhibitors for Sirt5 with <i>K</i>_i values in the low nanomolar range are lacking. We synthesized and screened 3-arylthio­succinylated and 3-benzylthio­succinylated peptide derivatives yielding Sirt5 inhibitors with low-nanomolar <i>K</i>_i values. A biotinylated derivative with this scaffold represents an affinity probe for human Sirt5 that is able to selectively extract this enzyme out of complex biological samples like cell lysates. Crystal structures of Sirt5/inhibitor complexes reveal that the compounds bind in an unexpected manner to the active site of Sirt5

Chinese Whispers? The Congruence Between Maltese FE Organizations’ Missions and Government Policy For the Sector

This paper delineates the assessed alignment between the Maltese government’s policy for the further education sector (FE) and FE organizations’ missions. Since alignment is multifaceted, a complementarity blended approach was used to help uncover its complexities. Data were collected from seven FE vocational and academic organizations via questionnaires to academic staff; interviews with principals and other internal and external stakeholders; content analysis of mission statements. Data showed that there is only moderate alignment between organizational mission and government policy with large vocational organizations displaying more alignment with such policies.The use of a complementarity blended method may be useful to explain educational alignment in other small states. Short bureaucratic distances are not a guarantee of alignment

Bioinspired Molecular Lantern: Tuning the Firefly Oxyluciferin Emission with Host–Guest Chemistry

Fireflies generate flashes of visible light via luciferase-catalyzed chemiexcitation of the substrate (luciferin) to the first excited state of the emitter (oxyluciferin). Microenvironment effects are often invoked to explain the effects of the luciferase active pocket on the emission; however, the exceedingly complex spectrochemistry and synthetic burdens have precluded elucidation of the nature of these interactions. To decipher the effects of microenvironment on the light emission, here the hydrophobic interior of cucurbit[7]­uril (CB7) is used to mimic the nonpolar active pocket of luciferase. The hydrophobic interior of CB7 induces shifts of the ground-state p<i>K</i>_as by 1.9–2.5 units to higher values. Upon sequestration, the emission maxima of neutral firefly oxyluciferin and its conjugate monodeprotonated base are blue-shifted by 40 and 39 nm, respectively, resulting in visual color changes of the emitted light